Effects of tetrandrine on apoptosis and radiosensitivity of nasopharyngeal carcinoma cell line CNE.

@article{Sun2007EffectsOT,
  title={Effects of tetrandrine on apoptosis and radiosensitivity of nasopharyngeal carcinoma cell line CNE.},
  author={Xinchen Sun and Ruizhi Xu and Yuxia Deng and Hongyan Cheng and Jun Ma and Jiazhong Ji and Yingfeng Zhou},
  journal={Acta biochimica et biophysica Sinica},
  year={2007},
  volume={39 11},
  pages={869-78}
}
Tetrandrine is known to exert antitumor effect, however, little is known about its effect on nasopharyngeal carcinoma cells. In this study, we tested tetrandrine-induced apoptosis and radiosensitivity in nasopharyngeal carcinoma cell line CNE and investigated the possible mechanisms. Using flow cytometry and DNA electrophoresis, we found that tetrandrine could induce cell apoptosis. Further, it was shown that the level of Bcl-2 mRNA decreased and Bax mRNA increased after addition of tetrandrine… CONTINUE READING

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