Effects of tetracycline and diazepam on insulin secretion and adenylyl cyclase activity of isolated rat islets of Langerhans.

@article{elDenshary1977EffectsOT,
  title={Effects of tetracycline and diazepam on insulin secretion and adenylyl cyclase activity of isolated rat islets of Langerhans.},
  author={E S el-Denshary and N. A. Ismail and William Montague},
  journal={Diabete & metabolisme},
  year={1977},
  volume={3 1},
  pages={3-6}
}
Tetracycline (2 and 20 micronM) inhibited glucose-stimulated insulin secretion from isolated rat islets of Langerhans, although it failed to alter tolbutamide-stimulated insulin release. Diazepam (10 micronM) potentiated tolbutamide-stimulated insulin release and at a concentration of 1 mM increased glucose-stimulated insulin release. Tetracycline (20 and… CONTINUE READING