Effects of tetracaine on displacement currents and contraction of frog skeletal muscle.

@article{Almers1976EffectsOT,
  title={Effects of tetracaine on displacement currents and contraction of frog skeletal muscle.},
  author={Wolfhard Almers and Philip M. Best},
  journal={The Journal of physiology},
  year={1976},
  volume={262 3},
  pages={583-611}
}
The kinetics of mechanical activation of intact fibres were examined with a voltage-clamp technique. Tetracaine (2 mM) increases fifteen- to seventyfold the time required to produce a just visible contraction by cell membrane depolarization. 2. Displacement currents thought to be related to contractile activation remain in 2 mM tetracaine. Their characteristics are virtually identical to those found in the absence of the drug. Displacement currents also remain in fibres immobilized by treatment… CONTINUE READING

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