Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol.

@article{Janele2006EffectsOT,
  title={Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol.},
  author={David Janele and Thomas G Lang and Silvia Capellino and Maurizio Cutolo and Jos{\'e} Ant{\'o}nio Pereira da Silva and Rainer H Straub},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1069},
  pages={168-82}
}
Estrogens at physiological concentrations are thought to play an immune-stimulating role, whereas androgens have an anti-inflammatory impact. However, their role on cytokine secretion in the presence or absence of cortisol has not been investigated. Furthermore, the role of hydroxylated estrogens downstream of 17beta-estradiol (E2) on secretion of tumor necrosis factor (TNF) is not known. In this study on peripheral blood leukocytes of healthy male subjects, we scrutinized the influence of… CONTINUE READING
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