Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase.

@article{Peebles2006EffectsOT,
  title={Effects of terpenoid precursor feeding on Catharanthus roseus hairy roots over-expressing the alpha or the alpha and beta subunits of anthranilate synthase.},
  author={Christie A M Peebles and Seung-beom Hong and Susan I. Gibson and Jacqueline V. Shanks and Ka-Yiu San},
  journal={Biotechnology and bioengineering},
  year={2006},
  volume={93 3},
  pages={534-40}
}
Among the pharmacologically important terpenoid indole alkaloids produced by Catharanthus roseus are the anti-cancer drugs vinblastine and vincristine. These two drugs are produced in small yields within the plant, which makes them expensive to produce commercially. Metabolic engineering has focused on increasing flux through this pathway by various means such as elicitation, precursor feeding, and introduction of genes encoding specific metabolic enzymes into the plant. Recently in our lab, a… CONTINUE READING
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