Effects of tenidap on intracellular signal transduction and the induction of proinflammatory cytokines: a review.

@article{Bondeson1996EffectsOT,
  title={Effects of tenidap on intracellular signal transduction and the induction of proinflammatory cytokines: a review.},
  author={J. Bondeson},
  journal={General pharmacology},
  year={1996},
  volume={27 6},
  pages={
          943-56
        }
}
  • J. Bondeson
  • Published 1996
  • Medicine
  • General pharmacology
  • Tenidap is a novel, once-daily antirheumatic drug which has shown promising results against rheumatoid arthritis in extensive clinical trials. It combines NSAID-like cyclooxygenase inhibition with suppression of the acute phase response. In macrophages, tenidap inhibits the lipopolysaccharide-induced synthesis of interleukins-1 and -6, but it tends to potentiate the lipopolysaccharide-induced synthesis of tumor necrosis factor alpha, due to its cyclooxygenase inhibition. In macrophages, tenidap… CONTINUE READING
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