Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.

@article{Cuzzocrea2000EffectsOT,
  title={Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.},
  author={Salvatore Cuzzocrea and Michelle C McDonald and Emanuela Mazzon and Dilani Siriwardena and Giuseppina Costantino and Francesco Fulia and Giovanni Cucinotta and Eloisa Gitto and Santa Cordaro and Ignazio Barberi and Angela De Sarro and Achille Patrizio Caputi and Cristoph Thiemermann},
  journal={Brain research},
  year={2000},
  volume={875 1-2},
  pages={96-106}
}
There is evidence that the excessive generation of reactive-oxygen radicals contributes to the brain injury associated with transient, cerebral ischemia. This study investigates the effects of tempol, a small, water-soluble molecule, that crosses biological membranes, on the brain injury caused by bilateral occlusion and reperfusion of both common carotid arteries in the gerbil (BCO). Treatment of gerbils with tempol (30 mg/kg i.p. at 30 min prior to reperfusion and at 1 and 6 h after the onset… CONTINUE READING
37 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…