Effects of temperature on slow and fast inactivation of rat skeletal muscle Na(+) channels.

  title={Effects of temperature on slow and fast inactivation of rat skeletal muscle Na(+) channels.},
  author={R. Ruff},
  journal={The American journal of physiology},
  volume={277 5},
  • R. Ruff
  • Published 1999
  • Chemistry, Medicine
  • The American journal of physiology
  • Patch-clamp studies of mammalian skeletal muscle Na(+) channels are commonly done at subphysiological temperatures, usually room temperature. However, at subphysiological temperatures, most Na(+) channels are inactivated at the cell resting potential. This study examined the effects of temperature on fast and slow inactivation of Na(+) channels to determine if temperature changed the fraction of Na(+) channels that were excitable at resting potential. The loose patch voltage clamp recorded Na… CONTINUE READING
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