Effects of temperature on slow and fast inactivation of rat skeletal muscle Na(+) channels.

@article{Ruff1999EffectsOT,
  title={Effects of temperature on slow and fast inactivation of rat skeletal muscle Na(+) channels.},
  author={Robert L. Ruff},
  journal={The American journal of physiology},
  year={1999},
  volume={277 5},
  pages={
          C937-47
        }
}
Patch-clamp studies of mammalian skeletal muscle Na(+) channels are commonly done at subphysiological temperatures, usually room temperature. However, at subphysiological temperatures, most Na(+) channels are inactivated at the cell resting potential. This study examined the effects of temperature on fast and slow inactivation of Na(+) channels to determine if temperature changed the fraction of Na(+) channels that were excitable at resting potential. The loose patch voltage clamp recorded Na… CONTINUE READING

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