Effects of temperature and pressure during compression on polymorphic transformation and crushing strength of chlorpropamide tablets.

Abstract

The effects of temperature on the polymorphic transformation of chlorpropamide during compression and on the physical properties of the tablet have been investigated. A heater and liquid nitrogen pool were mounted on the die of a single punch eccentric tableting machine, and the die temperature was controlled by a thermocontroller. A tableting machine with… (More)

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