Effects of telmisartan and linagliptin when used in combination on blood pressure and oxidative stress in rats with 2-kidney-1-clip hypertension.

@article{Chaykovska2013EffectsOT,
  title={Effects of telmisartan and linagliptin when used in combination on blood pressure and oxidative stress in rats with 2-kidney-1-clip hypertension.},
  author={Lyubov Chaykovska and Markus L. Alter and Karoline von Websky and Margarete Hohmann and Oleg Tsuprykov and Christoph Reichetzeder and Barbara Kutil and Robin Kraft and Thomas Klein and Berthold Hocher},
  journal={Journal of hypertension},
  year={2013},
  volume={31 11},
  pages={2290-8; discussion 2299}
}
OBJECTIVE To investigate the effects of linagliptin alone and in combination with the angiotensin II receptor blocker (ARB), telmisartan on blood pressure (BP), kidney function, heart morphology and oxidative stress in rats with renovascular hypertension. METHODS Fifty-seven male Wistar rats underwent unilateral surgical stenosis of the renal artery [2-kidney-1-clip (2k1c) method]. Animals were randomly divided into four treatment groups (n = 14-18 per group) receiving: telmisartan (10 mg/kg… CONTINUE READING