Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities

@article{Pugsley2004EffectsOT,
  title={Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities},
  author={Thomas A. Pugsley and Wilbur Lippmann},
  journal={Psychopharmacology},
  year={2004},
  volume={47},
  pages={33-41}
}
Two novel agents, tandamine [TA; a thiopyrano (3,4-b) indole] and pirandamine [PA; an indeno (2,1-c) pyran], and the tricyclic antidepressants desimipramine (DMI), imipramine (I) and amitriptyline (A) were compared in various in vivo pharmacological tests and for norepinephrine (NE) and 5-hydroxytryptamine (5-HT) neuronal uptake inhibition. TA was found to be equivalent, or greater, in activity to DMI in blocking brain NE uptake, antagonizing reserpine-induced effects and potentiating the… 

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