Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction.

@article{Okutsu2010EffectsOT,
  title={Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction.},
  author={Hiroko Okutsu and Seiji Matsumoto and Tadashi Hanai and Yukiko Noguchi and Noriko Fujiyasu and Akiyoshi Ohtake and Masanori Suzuki and Shuichi Sato and Masao Sasamata and Hirotsugu Uemura and Takashi Kurita},
  journal={Urology},
  year={2010},
  volume={75 1},
  pages={235-40}
}
OBJECTIVES To investigate the mechanism underlying the ameliorating effect of tamsulosin, an alpha(1)-adrenoceptor antagonist, on storage symptoms associated with benign prostatic hyperplasia, the effects of tamsulosin on bladder blood flow (BBF) and bladder function was evaluated in rats with bladder outlet obstruction (BOO). METHODS BOO was produced by partial ligature of the proximal urethra, which was maintained for 2 weeks. Tamsulosin was subcutaneously administered via an osmotic pump… CONTINUE READING

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