Effects of tamoxifen on the female genital tract.

  title={Effects of tamoxifen on the female genital tract.},
  author={Tommy Fornander and Lars Erik Rutqvist and Nils Wilking},
  journal={Annals of the New York Academy of Sciences},
Tamoxifen is a widely used drug in medical oncology, mainly for treatment of breast cancer, but also for second line treatment of endometrial cancer. We recently reported an increased incidence of endometrial cancer associated with long-term adjuvant tamoxifen. This observation, previous reports of stimulatory effects of tamoxifen in the female genital tract, and experimental data are in accordance with a mainly estrogenic effect of tamoxifen in these tissues. An increased incidence of… CONTINUE READING