Effects of tamoxifen on insulin-like growth factors, IGF binding proteins and IGFBP-3 proteolysis in breast cancer patients.

@article{Grnbaek2003EffectsOT,
  title={Effects of tamoxifen on insulin-like growth factors, IGF binding proteins and IGFBP-3 proteolysis in breast cancer patients.},
  author={H Gr{\o}nbaek and Vasilios Tanos and Dror Meirow and Tamar Y. Peretz and Itamar Raz and Allan Flyvbjerg},
  journal={Anticancer research},
  year={2003},
  volume={23 3C},
  pages={
          2815-20
        }
}
BACKGROUND Recently an association between increased serum insulin-like growth factor I (IGF-I) levels and the development of breast cancer was demonstrated. Tamoxifen used in the postoperative treatment of breast cancer patients may exert significant effects on the IGF-I system. MATERIALS AND METHODS To examine the effect of Tamoxifen treatment (20 mg/day) on changes in the IGF-I axis in 11 breast cancer patients before and after 4 months of Tamoxifen treatment and compared to 8 healthy… CONTINUE READING

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