Effects of tacrolimus on dermatomyositis and polymyositis: a prospective, open, non-randomized study of nine patients and a review of the literature

@article{Matsubara2012EffectsOT,
  title={Effects of tacrolimus on dermatomyositis and polymyositis: a prospective, open, non-randomized study of nine patients and a review of the literature},
  author={Shiro Matsubara and Koichi Kondo and Keizo Sugaya and Kazuhito Miyamoto},
  journal={Clinical Rheumatology},
  year={2012},
  volume={31},
  pages={1493-1498}
}
Dermatomyositis (DM) and polymyositis (PM) are often refractory to conventional therapy with corticosteroids sometimes combined with immune-suppressing agents and can lead to severe disability if these treatments are unsuccessful. In this prospective, open, non-randomized study, we examined the efficacy of tacrolimus (FK506), an immunosuppressant, in nine patients with DM (n = 5) or PM (n = 4) who did not respond to previous therapy. Outcomes included compound muscle strength, ambulatory status… CONTINUE READING

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