Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.

@article{Kuo2005EffectsOS,
  title={Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy.},
  author={Lu-Ting Kuo and Andrew Bruce Simpson and Anne Sch{\"a}nzer and Jamie Tse and Shu-Feng An and Francesco Scaravilli and Michael Groves},
  journal={The Journal of comparative neurology},
  year={2005},
  volume={482 4},
  pages={
          320-32
        }
}
Previous work has shown that administration of the neurotrophin NT-3 intrathecally or to the proximal stump can prevent axotomy-induced sensory neuron loss and that NT-3 can stimulate sensory neuron differentiation in vitro. We have examined the effect of axotomy and systemic NT-3 administration on neuronal loss, apoptosis (defined by morphology and activated caspase-3 immunoreactivity), and nestin expression (a protein expressed by neuronal precursor cells) in dorsal root ganglia (DRG… CONTINUE READING
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