Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats.

@article{Culman1999EffectsOS,
  title={Effects of systemic treatment with irbesartan and losartan on central responses to angiotensin II in conscious, normotensive rats.},
  author={Juraj Culman and C von Heyer and B Piepenburg and Wolfgang Rascher and Thomas Unger},
  journal={European journal of pharmacology},
  year={1999},
  volume={367 2-3},
  pages={
          255-65
        }
}
Angiotensin AT1 receptor antagonists represent a novel class of cardiovascular drugs. In conscious, normotensive rats, irbesartan ((2-n-butyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl) methyl]-1,3-diaza-spiro[4,4]non) and losartan ((2 n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl -4-yl) methyl] imidazol), two specific, high- affinity angiotensin AT1 receptor antagonists administered intravenously (i.v.) at doses of 0.3, 1, 3 and 10 mg/kg body weight, or orally (p.o.) at doses… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 16 citations