Effects of systemic and local administration of etomidate on adrenocortical steroidogenesis in male rats.

H. Jarry; M. Dietrich; E. Düker; W. Wuttke

DOI:10.1530/ACTA.0.1140402

Corpus ID: 30870413

Effects of systemic and local administration of etomidate on adrenocortical steroidogenesis in male rats.

@article{Jarry1987EffectsOS,
  title={Effects of systemic and local administration of etomidate on adrenocortical steroidogenesis in male rats.},
  author={H. Jarry and M. Dietrich and E. D{\"u}ker and W. Wuttke},
  journal={Acta endocrinologica},
  year={1987},
  volume={114 3},
  pages={
          402-9
        }
}

H. Jarry, M. Dietrich, +1 author W. Wuttke

Published 1987

Medicine

Acta endocrinologica

A method for focal dialysis of the adrenal cortex is introduced allowing determination of adrenal steroid local release rates in conscious, freely moving rats. Etomidate, an anaesthetic drug known to interfere with adrenal steroid synthesis, blocks not only corticosterone but also aldosterone and, to a lesser degree, progesterone release. Intra-adrenal application of the drug via the dialysis system for a defined time resulted in low release rates of corticosterone without inducing sedation of… CONTINUE READING

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