Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat.

@article{Dziak1982EffectsOS,
  title={Effects of synthetic muramyl dipeptide on bone metabolism in the fetal rat.},
  author={R. Dziak and Dorothy J. Rowe and M J Brown and Ernest Hausmann},
  journal={Archives of oral biology},
  year={1982},
  volume={27 10},
  pages={
          787-91
        }
}

The effect of lipopolysaccharide from bacteroides gingivalis and muramyl dipeptide on osteoblast collagenase release

TLDR
LPS significantly stimulated collagenase levels compared to unstimulated controls and MDP did not significantly stimulate collagenase or TIMP levels, indicating that MDP may not interact with osteoblasts.

Induction of chronic arthritis in rats : the role of intestinal bacteria and bacterial cell wall fragments

TLDR
Evidence supporting the hypothesis that in rheumatoid anhritis intestinal flora derived antigens may be involved comes from studies in which cell wall fragments of aerobic and anaerobic Gram-positive intestinal bacteria are shown to induce arthritis after intraperitoneal injection in rats (intraperitoneal model).

Lipoprotein: a gram-negative cell wall component that stimulates bone resorption.

TLDR
Lipoprotein (free-form) from Escherichia coli was shown to stimulate in vitro bone resorption in a fetal rat model system and the potency was comparable to that of lipopolysaccharides from various bacterial species.

The quest for better understanding of HLA-disease association: scenes from a road less travelled by.

TLDR
An alternative theory involving allele-based, antigen presentation-independent mechanism is proposed here, and recent research findings in rheumatoid arthritis lend support to the proposed theory.

Benzo(B)Thiophene-2-Carboxylic acid: Calcium uptake and cyclic AMP production in isolated bone cells

TLDR
BL-5583 inhibited spontaneous as well as A23187 and PTH-induced bone resorption in tissue culture and induced a transient decrease in calcium uptake in skin cells isolated from fetal rats by collagenase digestion, suggesting a lack of tissue specificity for this compound.

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Macrophage activation by mycobacterial water soluble compounds and synthetic muramyl dipeptide.

TLDR
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TLDR
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TLDR
Increasing the phosphate concentration of the medium over the range of 0.25 to 4M produced a decreased release of calcium from bone, particularly in response to parathyroid hormone, demonstrating that active resorption was inhibited.

Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone.

TLDR
Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations, implying that cell replication is not required for osteoclast formation in fetalRat long bone cultures.

Target cells in bone for parathormone and calcitonin are different: enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces.

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TLDR
It is established that bone contains at least two types of target cells--one that responds to parathormone but not calcitonin, the other that responds predominantly to calciton in an asymmetric bipolar morphology.

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Endochondral osteogenesis was studied autoradiographically in ribs and tibiae of 32 Long-Evans rats injected with 1 µc/gm H3-thymidine at 6 days of age and sacrificed at intervals between 1 hour and