Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer.

@article{Vassileva2008EffectsOS,
  title={Effects of sustained and intermittent paclitaxel therapy on tumor repopulation in ovarian cancer.},
  author={Vessela Vassileva and Christine J Allen and Micheline Piquette-Miller},
  journal={Molecular cancer therapeutics},
  year={2008},
  volume={7 3},
  pages={630-7}
}
Tumor repopulation between cycles of chemotherapy likely has a negative effect on clinical outcome in ovarian cancer patients. Thus, avoiding treatment-free periods when tumor cells proliferate by providing sustained chemotherapy regimens may improve clinical response. We investigated the effect of sustained versus intermittent paclitaxel administration on tumor repopulation in ovarian cancer. Growth, clonogenic survival, and apoptosis were followed in SKOV3 and A2780 cells after equivalent… CONTINUE READING

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