Effects of surgical manipulation of the intestine on peptide YY and its physiology

@article{Imamura2002EffectsOS,
  title={Effects of surgical manipulation of the intestine on peptide YY and its physiology},
  author={Mikio Imamura},
  journal={Peptides},
  year={2002},
  volume={23},
  pages={403-407}
}
  • M. Imamura
  • Published 1 February 2002
  • Medicine, Biology
  • Peptides
Neuropeptide Y receptors; antisecretory control of intestinal epithelial function
  • H. Cox
  • Biology
    Autonomic Neuroscience
  • 2007
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Elevation of plasma peptide YY and pancreatic juice hypersecretion following massive small bowel resection in the rat.
TLDR
It is considered that, in a malnutritional state after small intestinal resection, a colonic regulatory mechanism, via humoral factors such as PYY, participates in the feedback regulation of proximal intestinal as well as of pancreatic function.
Evidence for regulation of peptide-YY release by the proximal gut.
TLDR
The results of these experiments indicate that the release of PYY from the distal ileum and colon is controlled, at least in part, by an extramural neural, endocrine, or a combination of both types of mechanisms which originate in the foregut.
Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.
TLDR
PYY is a potent proabsorptive agent in the colon of the conscious dog and may be useful clinical agents in intestinal malabsorptive disorders or after bowel resection.
Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?
TLDR
Plasma PYY correlates both with crypt cell production rate in the ileum and with plasma enteroglucagon levels, and it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.
Release of peptide YY (PYY) after resection of small bowel, colon, or pancreas in man.
TLDR
PYY does not appear to have a role in the adaptive trophic response after small intestinal resection, but it may contribute to reduction of gastric secretion and gastrointestinal transit in patients with resected small or large intestines.
Fat-induced ileal brake in the dog depends on peptide YY.
TLDR
Fat-induced ileal brake depends on PYY, and the role of this peptide remains to be confirmed because systemic PYY may not exert its effect by the same regulatory pathway as fat- induced ILEal brake.
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