Neuropeptide Y receptors; antisecretory control of intestinal epithelial function
- BiologyAutonomic Neuroscience
News in gut‐brain communication: a role of peptide YY (PYY) in human obesity and following bariatric surgery?
- Medicine, BiologyEuropean journal of clinical investigation
Recent advances in obesity research focused on neuroendocrine control of food intake, appetite and body weight balance. Gut hormones, which are sequentially released from different regions of the…
Gastrointestinal Hormones Controlling Energy Homeostasis and Their Potential Role in Obesity
This work focuses on some of the key GI hormones believed to play a relevant role in the control of the energy homeostasis: ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine-tyrosine (PYY), oxyntomodulin (OXM), pancreatic polypeptide (PP), and somatostatin (SST).
Peptide YY Induces Intestinal Proliferation in Peptide YY Knockout Mice With Total Enteral Nutrition After Massive Small Bowel Resection
- MedicineJournal of pediatric gastroenterology and nutrition
In an SBR model of Pyy−/− mice, PYY induces proliferation of residual intestine with TEN, which shows a significant increase in bowel and mucosal weights, mucosal DNA and protein, villus height, and crypt depth in jejunum and ileum.
Adaptive changes of the enterochromaffin and gastrin cells in the rat gastrointestinal tract following subtotal colectomy
- Medicine, BiologyScandinavian journal of gastroenterology
The results indicate that colectomy exerts a significant influence on the GI mucosa and on the endocrine cell systems studied.
Peptide YY, appetite and food intake
- Biology, MedicineProceedings of the Nutrition Society
PYY3-36 appears to control food intake by providing a powerful feedback on the hypothalamic circuits and may be important in the everyday regulation of food intake.
The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on.
- MedicineAnnual review of physiology
This narrative review critically discusses recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role in glucose homeostasis, the roles of hepatoportal PYYIn mediating its central physiological effects, the specific modulation of brain regions by PYY, and the exercise-induced PYY response.
Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y1 and Y2 receptors
- Medicine, BiologyBritish journal of pharmacology
The gastrointestinal consequences of selective PYY or NPY ablation on mucosal ion transport, smooth muscle activity and transit using wild‐type, single and double peptide knockout mice are investigated, comparing mucosal responses with those from human colon.
SHOWING 1-10 OF 37 REFERENCES
Elevation of plasma peptide YY and pancreatic juice hypersecretion following massive small bowel resection in the rat.
- MedicineThe Tohoku journal of experimental medicine
It is considered that, in a malnutritional state after small intestinal resection, a colonic regulatory mechanism, via humoral factors such as PYY, participates in the feedback regulation of proximal intestinal as well as of pancreatic function.
Evidence for regulation of peptide-YY release by the proximal gut.
- Medicine, BiologyEndocrinology
The results of these experiments indicate that the release of PYY from the distal ileum and colon is controlled, at least in part, by an extramural neural, endocrine, or a combination of both types of mechanisms which originate in the foregut.
Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.
- MedicineThe American surgeon
PYY is a potent proabsorptive agent in the colon of the conscious dog and may be useful clinical agents in intestinal malabsorptive disorders or after bowel resection.
A physiological role of peptide YY on exocrine pancreatic secretion in rats.
- Medicine, BiologyGastroenterology
Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?
Plasma PYY correlates both with crypt cell production rate in the ileum and with plasma enteroglucagon levels, and it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.
Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK☆
- Biology, MedicinePeptides
Peptide YY release by fatty acids is sufficient to inhibit gastric emptying in dogs.
- Medicine, BiologyGastroenterology
Release of peptide YY (PYY) after resection of small bowel, colon, or pancreas in man.
PYY does not appear to have a role in the adaptive trophic response after small intestinal resection, but it may contribute to reduction of gastric secretion and gastrointestinal transit in patients with resected small or large intestines.
Fat-induced ileal brake in the dog depends on peptide YY.
Fat-induced ileal brake depends on PYY, and the role of this peptide remains to be confirmed because systemic PYY may not exert its effect by the same regulatory pathway as fat- induced ILEal brake.
Intraileal carbohydrate regulates canine postprandial pancreaticobiliary secretion and upper gut motility.