Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy.

@article{Czabanka2009EffectsOS,
  title={Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy.},
  author={M Czabanka and Mara Vinci and Frank Heppner and Axel Ullrich and Peter Vajkoczy},
  journal={International journal of cancer},
  year={2009},
  volume={124 6},
  pages={
          1293-300
        }
}
Current clinical protocols favor a combination of antiangiogenic/antivascular compounds with classical chemotherapy. However, it remains unclear to what extent an antiangiogenic/antivascular therapy influences the delivery of chemotherapy. Therefore, the aim of the present study was to characterize the effects of the antiangiogenic tyrosine kinase inhibitor sunitinib on tumor microhemodynamics and delivery of chemotherapy. SF126 tumor cells were implanted subcutaneously into nude mice and were… CONTINUE READING

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