Effects of sulfuric acid and nitrogen dioxide on airway responsiveness of the guinea pig.

Hartley guinea pigs were exposed for 1 h to either NO2 gas of H2SO4 aerosol and examined for changes in airway responsiveness to inhaled histamine. Concentrations ranged from 7 to 146 ppm NO2 and 4 to 40 mg/m3 H2SO4. One group of animals exposed to filtered air served as controls. Histamine challenges were performed on unanesthetized animals 2 h before… CONTINUE READING