Effects of substance P on neurones of the inferior mesenteric ganglia of the guinea-pig.

@article{Dun1981EffectsOS,
  title={Effects of substance P on neurones of the inferior mesenteric ganglia of the guinea-pig.},
  author={Nae J. Dun and Shoichi Minota},
  journal={The Journal of physiology},
  year={1981},
  volume={321},
  pages={259-71}
}
1. The membrane effects of substance P on neurones of isolated inferior mesenteric ganglia and the underlying ionic mechanisms were investigated by means of intracellular recording techniques.2. When applied to the neurones by superfusion, substance P (0.5 mum) caused a membrane depolarization; in a few neurones, the depolarization was preceded by a small hyperpolarization. Substance P effects were not altered in a low Ca(2+)/high Mg(2+) solution or in a solution containing d-tubocurarine and… CONTINUE READING
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