Effects of substance P on human colonic mucosa in vitro.

  title={Effects of substance P on human colonic mucosa in vitro.},
  author={Markus Riegler and Ignazio Castagliuolo and Peter So and Miriam Lotz and Chi Wang and Michael Wlk and Tacettin Sogukoglu and Elena Cosentini and Georg Bischof and Garth Hamilton and B{\'e}la T{\'e}leky and Etienne Wenzl and Jeffrey B. Matthews and Charalabos Pothoulakis},
  journal={The American journal of physiology},
  volume={276 6 Pt 1},
Previous studies indicated that the peptide substance P (SP) causes Cl--dependent secretion in animal colonic mucosa. We investigated the effects of SP in human colonic mucosa mounted in Ussing chamber. Drugs for pharmacological characterization of SP-induced responses were applied 30 min before SP. Serosal, but not luminal, administration of SP (10(-8) to 10(-6) M) induced a rapid, monophasic concentration and Cl--dependent, bumetanide-sensitive short-circuit current (Isc) increase, which was… CONTINUE READING
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