Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats.

@article{Kertes2009EffectsOS,
  title={Effects of substance P microinjections into the globus pallidus and central nucleus of amygdala on passive avoidance learning in rats.},
  author={Erika Kertes and Krist{\'o}f L{\'a}szl{\'o} and Be{\'a}ta Berta and L{\'a}szl{\'o} L{\'e}n{\'a}rd},
  journal={Behavioural brain research},
  year={2009},
  volume={198 2},
  pages={397-403}
}
Substance P (SP) has been implicated in learning and memory processes. This peptide facilitated learning when injected peripherally or directly into the ventral pallidum. SP has high affinity for neurokinin-1 (NK-1) receptors. WIN51,708 is a potent NK-1 receptor antagonist that can inhibit the physiological effects of SP. Immunohistochemical experiments showed that the globus pallidus (GP) and the amygdaloid (AMY) body are rich in SP immunoreactive elements. Pallidal lesions cause learning… CONTINUE READING

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