Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy.

@article{Nagano2003EffectsOS,
  title={Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy.},
  author={Takashi Nagano and Masatsugu Nakamura and Katsuhiko Nakata and Takeshi Yamaguchi and Kenji Takase and Akihiko Okahara and Toshimi Ikuse and Teruo Nishida},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 9},
  pages={3810-5}
}
PURPOSE To establish a rat model of neurotrophic keratopathy and to examine the effects of the combination of substance P (SP) and insulin-like growth factor (IGF)-1 on corneal epithelial barrier function and wound healing in this model. METHODS Corneal denervation was achieved by thermocoagulation of the ophthalmic branch of the trigeminal nerve. A modified Schirmer test was performed without topical anesthesia. Corneal epithelial barrier function was assessed by measurement of fluorescein… CONTINUE READING