Effects of subcutaneous versus intravenous administration of cyclosporin A on rat thymic histology and pharmacokinetics.

Abstract

Cyclosporin A (CsA) was administered to rats by repeated subcutaneous (s.c.) or intravenous (i.v.) injections for 14 days. Changes in thymic histology were independent of the route of administration. Blood concentration--time profiles of CsA were similar at dose levels of i.v. 7.5 and s.c. 15 mg/kg/day, respectively. So, provided that the dose is reduced, i… (More)

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@article{Waal1992EffectsOS, title={Effects of subcutaneous versus intravenous administration of cyclosporin A on rat thymic histology and pharmacokinetics.}, author={Eric J de Waal and Henk-Jan Schuurman and Coenraad F. M. Hendriksen and Bert H Elvers and Addy van Dijk and Henk van Loveren}, journal={International journal of immunopharmacology}, year={1992}, volume={14 6}, pages={1101-5} }