Effects of subconjunctival administration of anti-high mobility group box 1 on dry eye in a mouse model of Sjӧgren’s syndrome

@inproceedings{Kim2017EffectsOS,
  title={Effects of subconjunctival administration of anti-high mobility group box 1 on dry eye in a mouse model of Sjӧgren’s syndrome},
  author={Kyeong Hwan Kim and Dong Hyun Kim and Hyun Jeong Jeong and Jin Suk Ryu and Yu Jeong Kim and Joo Youn Oh and Mee Kum Kim and Won Ryang Wee},
  booktitle={PloS one},
  year={2017}
}
PURPOSE Extracellular high mobility group box 1 (HMGB1) acts as a damage associated molecular pattern molecule through the Toll-like receptor to promote autoreactive B cell activation, which may be involved in the pathogenesis of Sjӧgren's syndrome. The aim of this study was to investigate the effect of subconjunctival administration of anti-HMGB1 on dry eye in a mouse model of Sjӧgren's syndrome. METHODS Ten weeks-old NOD.B10.H2b mice were subconjunctivally injected with 0.02 to 2 μg of anti… CONTINUE READING

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