Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.

@article{Elder2005EffectsOS,
  title={Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.},
  author={Alison C P Elder and Robert Gelein and Jacob N. Finkelstein and Kevin E Driscoll and Jack N Harkema and G{\"u}nther Oberd{\"o}rster},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={88 2},
  pages={614-29}
}
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or hamsters, presumably due to secondary genotoxic mechanisms involving persistent lung inflammation and injury. We hypothesized that the lung inflammation and injury induced by subchronic inhalation of Cb are more pronounced in rats than in mice and hamsters. Particle retention kinetics, inflammation, and histopathology were examined in female rats, mice, and hamsters exposed for 13 weeks to high… CONTINUE READING