Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat

@article{Trevitt1998EffectsOS,
  title={Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat},
  author={Jennifer T. Trevitt and Arlene Atherton and Juliet Aberman and John D Salamone},
  journal={Psychopharmacology},
  year={1998},
  volume={137},
  pages={61-66}
}
Clozapine, thioridazine (THIO) and haloperidol were administered for 14 consecutive days, and separate groups of rats were used to study the effects of these drugs on tremulous jaw movements and lever pressing. Rats were observed on day 13 for the ability of the antipsychotic drugs to induce jaw movements. Haloperidol produced a dose-related increase in jaw movements, while clozapine and THIO failed to induce jaw movements. On day 14, rats were challenged with 5.0 mg/kg of the… CONTINUE READING
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