Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.

@article{Parks1999EffectsOS,
  title={Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.},
  author={Robin J Parks and Jonathan L Bramson and Yakun Wan and Christina L Addison and Frank L. Graham},
  journal={Journal of virology},
  year={1999},
  volume={73 10},
  pages={8027-34}
}
We have analyzed transgene (lacZ) expression from a first-generation adenovirus (Ad) vector in comparison to helper-dependent (hd) Ads deleted for various portions of the viral coding sequences and generated by using the Cre/loxP helper-dependent system (R. J. Parks et al., Proc. Natl. Acad. Sci. USA 93:13565-13570, 1996). An hd vector deleted for approximately 70% of the Ad genome (AdRP1001) provided levels and durations of transgene expression similar to those of a control first generation Ad… CONTINUE READING
39 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Similar Papers

Loading similar papers…