Effects of structurally different (Leu5) enkephalinamides on electrically-evoked contractions of guinea pig ileum.

Abstract

The incorporation of D-Leu5 and the substitution of L-Gly2 by D-Ala2 into (Leu5)enkephalinamide, using direct coupling of enzymatic and azide methods for peptide bond formation, increased the relative potency of (Leu5)enkephalinamides to inhibit the electrically-evoked contractions of guinea pig ileum, probably activating a delta-type opiate receptor. 

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