Effects of stress throughout the lifespan on the brain, behaviour and cognition

@article{Lupien2009EffectsOS,
  title={Effects of stress throughout the lifespan on the brain, behaviour and cognition},
  author={Sonia J. Lupien and Bruce S. McEwen and Megan R. Gunnar and Christine Heim},
  journal={Nature Reviews Neuroscience},
  year={2009},
  volume={10},
  pages={434-445}
}
Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies… Expand

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References

SHOWING 1-10 OF 226 REFERENCES
Glucocorticoids, developmental 'programming' and the risk of affective dysfunction.
  • J. Seckl
  • Psychology, Medicine
  • Progress in brain research
  • 2008
TLDR
Pregnant stress/glucocorticoid overexposure causes permanent cardiometabolic, neuroendocrine and behavioural effects in offspring, and underlying epigenetic changes in target gene promoters may ensure persistence of altered transcription long after the initial challenge. Expand
HPA function in adolescence: Role of sex hormones in its regulation and the enduring consequences of exposure to stressors
TLDR
There is a growing evidence that exposure to stressors in adolescence may alter behavioural responses to drugs and cognitive performance in adulthood, however, the effects reported appear to be stressor-specific and sex-specific. Expand
Stress, sensitive periods and maturational events in adolescent depression
TLDR
An overview of how the maturation of specific brain regions and stress exposure during windows of vulnerability initiate a series of events that render adolescents exceptionally susceptible to the development of depression is provided. Expand
Stress during adolescence alters behavioral sensitization to amphetamine
TLDR
It is concluded that the chronic variable social stress protocol during adolescence inhibits behavioral sensitization to amphetamine during adulthood. Expand
Long‐term effects of prenatal stress and postnatal handling on age‐related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat
TLDR
Results show that the altered glucocorticoid secretion induced by early environmental manipulations is primary to the cognitive alterations observed only later in life and could be one cause of age‐related memory deficits. Expand
Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable?
TLDR
Preclinical studies on the effects of exposure to early life stress can demonstrate causality, and can enrich the understanding of the clinical research if they hypothesize that the consequences of early abuse are predominantly mediated through the induction of stress responses. Expand
Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects
TLDR
Using a novel immature-rodent model, the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks are described and the cellular mechanisms involved are reviewed. Expand
Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion
TLDR
Results suggest that individual differences in adult emotional status may be governed by early environmental factors; however, perinatal experiences are not effective in influencing adult memory capacity. Expand
Chronic stress: Implications for neuronal morphology, function and neurogenesis
TLDR
One of the challenges for future research is to link the cellular changes seen in animal models for chronic stress to behavioral effects and to understand the risks they can impose on humans for the precipitation of stress-related disorders. Expand
Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat.
TLDR
The results indicate that an exposure to a relatively brief juvenile stressful experience has profound and long-lasting effects on the ability to cope with stress in adulthood. Expand
...
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4
5
...