Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain

@article{Qu2011EffectsOS,
  title={Effects of streptozotocin-induced diabetes on tau phosphorylation in the rat brain},
  author={Zhongsen Qu and Zongxian Jiao and Xiaojiang Sun and Yuwu Zhao and Guogang Xu},
  journal={Brain Research},
  year={2011},
  volume={1383},
  pages={300-306}
}
Brain protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) activities are adaptable to changes of peripheral blood glucose level in vivo. GSK-3 phosphorylates microtube-associated protein tau at multiple sites, which can be antagonized by protein phosphatase-2A (PP-2A). The imbalance among these enzymes might have potential connections with diabetes mellitus (DM) and Alzheimer's disease (AD). In this study hyperglycemia rat DM model was achieved by streptozotocin (STZ) treatment. The… CONTINUE READING

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