Effects of streptozotocin-induced diabetes on rat liver sulfotransferase gene expression.

@article{RungeMorris1995EffectsOS,
  title={Effects of streptozotocin-induced diabetes on rat liver sulfotransferase gene expression.},
  author={Melissa Ann Runge-Morris and C Vento},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 4},
  pages={
          455-9
        }
}
The effects of streptozotocin (STZ)-induced diabetes on rat hepatic hydroxysteroid sulfotransferase-a (HST-a) and aryl sulfotransferase IV (ASTIV) gene expression were characterized. Female Sprague-Dawley rats (aged approximately 55 days) were treated with increasing doses of STZ (65, 120, or 175 mg/kg ip) and killed 48 hr later. In some groups, diabetic rats were rendered normoglycemic with insulin before killing. STZ produced a dose-dependent increase in serum glucose levels and a dose… CONTINUE READING