Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters.

@article{Py2002EffectsOS,
  title={Effects of streptozotocin-induced diabetes on markers of skeletal muscle metabolism and monocarboxylate transporter 1 to monocarboxylate transporter 4 transporters.},
  author={Guillaume Py and Karen Lambert and Ollivier Milhavet and Nicolas Eydoux and Christian G. Prefaut and J. M. Mercier},
  journal={Metabolism: clinical and experimental},
  year={2002},
  volume={51 7},
  pages={807-13}
}
Diabetes is known to alter both oxidative and glycolytic pathways in a fiber type-dependent manner. In various skeletal muscles of normal rats, monocarboxylate transporter 1 (MCT1) has been found to be highly correlated to lactate uptake, as well as to oxidative capacity, whereas the distribution and characteristics of MCT4 make it a good candidate for the extrusion of lactic acid from glycolytic muscle cells. Since a previous study found decreased sarcolemmal lactate uptake in streptozotocin… CONTINUE READING

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Soleus ( SOL ) , red tibialis anterior ( RTA ) , extensor digitorus longus ( EDL ) , heart , and preparations of purified sarcolemmal vesicles ( SV ) from control and STZ - diabetic rats were harvested for MCT1 and MCT4 content , citrate synthase activity ( CS ) , and lactate dehydrogenase ( LDH ) isozymes .
Soleus ( SOL ) , red tibialis anterior ( RTA ) , extensor digitorus longus ( EDL ) , heart , and preparations of purified sarcolemmal vesicles ( SV ) from control and STZ - diabetic rats were harvested for MCT1 and MCT4 content , citrate synthase activity ( CS ) , and lactate dehydrogenase ( LDH ) isozymes .
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