Effects of streptozotocin-induced diabetes on glucose transport in skeletal muscle.

@article{Barnard1990EffectsOS,
  title={Effects of streptozotocin-induced diabetes on glucose transport in skeletal muscle.},
  author={R. James Barnard and Jack F. Youngren and D S Kartel and Don Antonio Martin},
  journal={Endocrinology},
  year={1990},
  volume={126 4},
  pages={1921-6}
}
Female Sprague-Dawley rats were injected with streptozotocin (45 mg/kg) to induce mild diabetes (glucose, greater than 13 mM). Half of the animals received daily insulin injections to reduce hyperglycemia. After 10 weeks, sarcolemmal membranes were isolated from hindlimb muscles to study glucose transport, and the number of glucose transporters was assessed by cytochalasin-beta binding. Both glucose transport (19.2 +/- 1.6 vs. 31.93 +/- 3.29 pmol/mg protein.15 sec) and cytochalasin-beta binding… CONTINUE READING