Effects of statins on myocarditis: A review of underlying molecular mechanisms.

  title={Effects of statins on myocarditis: A review of underlying molecular mechanisms.},
  author={Negin Parsamanesh and Morteza Karami-Zarandi and Maciej Banach and Peter E. Penson and Amirhossein Sahebkar},
  journal={Progress in cardiovascular diseases},
HMG-CoA Reductase Inhibitor, Simvastatin Is Effective in Decreasing Degree of Myocarditis by Inhibiting Metalloproteinases Activation
The cardioprotective effects of simvastatin in the acute phase of EAM are, at least in part, due to its ability to decrease MMP-9 activity and subsequent decline in myofilaments degradation and suppression of inflammation.
Rosuvastatin exerts cardioprotective effect in lipopolysaccharide-mediated injury of cardiomyocytes in an MG53-dependent manner
RS exerts cardioprotective effect in an MG53-dependent manner, and MG53 may serve as a novel drug target for myocarditis treatment.
COVID-19 and cardiovascular complications – preliminary results of the LATE-COVID study
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Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review.
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B10 cells decrease fibrosis progression following cardiac injury partially by IL‐10 production and regulating hyaluronan secretion
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Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry
Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed


Diagnosis of myocarditis: death of Dallas criteria.
The studies raise the question of whether the current histopathological criteria for myocardial inflammation (the Dallas criteria) are sensitive enough to identify the population with viral or autoimmune-related heart compromise.
Statins and inflammation in cardiovascular disease.
Basic pathophysiologic data supporting the anti-inflammatory actions of statins in clinical and experimental settings are presented and link these mechanisms with confirmatory clinical data on the potent non lipid lowering effects of HMG-CoA reductase inhibitors.
Advancement of Mechanisms of Coxsackie Virus B3-Induced Myocarditis Pathogenesis and The Potential Therapeutic Targets.
Comparing information from findings of current studies on the potential therapeutic role of micro RNA, cytokines and chemokines on the mechanism of pathogenesis of Coxsackie virus B3- induced myocarditis is aimed at giving brief information for scholars to conduct a detailed study in the area.
The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review
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Hepatitis C virus infection and cardiomyopathies.
It is reported that mice transgenic for the HCV-core gene develop ventricular dilatation, cardiac dysfunction, and myocardial fibrosis at 12 months, similar to the pathological manifestations observed in human dilated cardiomyopathy.
Statins and inflammation: an update
Statins have anti-inflammatory properties that are clinically important in lowering cardiovascular risk, and it is probable, but not definitely proven, that some of the benefits of statins are due to their nonlipid effects.
Advances in the understanding of myocarditis.
The objective of this article is to better define myocarditis for both clinicians and clinical scientists by setting it in the framework of 3 phases of disease, in which the viral stage is reviewed, the autoimmune phase is examined and the remodeling processes are considered.
Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer
The pharmacology of the statins is reviewed, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes, and pathological conditions, and the disappointing evidence on the possible future use of statin-based drugs in cancer therapy is dissected.