Effects of statins on myocarditis: A review of underlying molecular mechanisms.

@article{Parsamanesh2021EffectsOS,
  title={Effects of statins on myocarditis: A review of underlying molecular mechanisms.},
  author={Negin Parsamanesh and Morteza Karami-Zarandi and Maciej Banach and Peter E. Penson and Amirhossein Sahebkar},
  journal={Progress in cardiovascular diseases},
  year={2021}
}
View on PubMed
researchonline.ljmu.ac.uk
7 Citations
Background Citations
3

7 Citations

Citation Type

Citation Type

HMG-CoA Reductase Inhibitor, Simvastatin Is Effective in Decreasing Degree of Myocarditis by Inhibiting Metalloproteinases Activation
TLDR
The cardioprotective effects of simvastatin in the acute phase of EAM are, at least in part, due to its ability to decrease MMP-9 activity and subsequent decline in myofilaments degradation and suppression of inflammation.
Rosuvastatin exerts cardioprotective effect in lipopolysaccharide-mediated injury of cardiomyocytes in an MG53-dependent manner
TLDR
RS exerts cardioprotective effect in an MG53-dependent manner, and MG53 may serve as a novel drug target for myocarditis treatment.
COVID-19 and cardiovascular complications – preliminary results of the LATE-COVID study
TLDR
Diabetes, elevated level of CRP and troponin, heart rate variability parameters and worsening of left ventricular ejection fraction are related to the severity of cardiovascular complications following COVID-19 infection.
Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review.
TLDR
This review highlighted the importance of various miRNAs and their potential role in fighting with respiratory viruses as therapeutic molecules with a focus on COVID-19.
B10 cells decrease fibrosis progression following cardiac injury partially by IL‐10 production and regulating hyaluronan secretion
TLDR
The frequency of B10 cells was significantly increased, and they participated in the regression of fibrosis via IL‐10, particularly by accelerating hyaluronan secretion and inhibiting collagen deposition, providing new evidence suggesting that B 10 cells exert antifibrotic effects by regulating the extracellular matrix composition during cardiac injury.
Nuclear and Radiological Emergencies: Biological Effects, Countermeasures and Biodosimetry
Atomic and radiological crises can be caused by accidents, military activities, terrorist assaults involving atomic installations, the explosion of nuclear devices, or the utilization of concealed…

References

SHOWING 1-10 OF 172 REFERENCES
Myocarditis
Effects of HMG-CoA Reductase Inhibitor on Experimental Autoimmune Myocarditis
TLDR
It is demonstrated that administration of rosuvastatin can ameliorate EAM progression, inhibit apoptosis of cardiomyocytes, and preserve cardiac output, and suggested rosuVastatin may be a promising novel therapeutic strategy for the clinical treatment of myocarditis.
Diagnosis of myocarditis: death of Dallas criteria.
TLDR
The studies raise the question of whether the current histopathological criteria for myocardial inflammation (the Dallas criteria) are sensitive enough to identify the population with viral or autoimmune-related heart compromise.
Statins and inflammation in cardiovascular disease.
TLDR
Basic pathophysiologic data supporting the anti-inflammatory actions of statins in clinical and experimental settings are presented and link these mechanisms with confirmatory clinical data on the potent non lipid lowering effects of HMG-CoA reductase inhibitors.
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization.
Advancement of Mechanisms of Coxsackie Virus B3-Induced Myocarditis Pathogenesis and The Potential Therapeutic Targets.
TLDR
Comparing information from findings of current studies on the potential therapeutic role of micro RNA, cytokines and chemokines on the mechanism of pathogenesis of Coxsackie virus B3- induced myocarditis is aimed at giving brief information for scholars to conduct a detailed study in the area.
The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review
Purpose of Review In this review, we discuss the evidence supporting the effects of statins on mast cells (MCs) in atherosclerosis and their molecular mechanism of action. Recent Findings Statins or…
Hepatitis C virus infection and cardiomyopathies.
TLDR
It is reported that mice transgenic for the HCV-core gene develop ventricular dilatation, cardiac dysfunction, and myocardial fibrosis at 12 months, similar to the pathological manifestations observed in human dilated cardiomyopathy.
Statins and inflammation: an update
TLDR
Statins have anti-inflammatory properties that are clinically important in lowering cardiovascular risk, and it is probable, but not definitely proven, that some of the benefits of statins are due to their nonlipid effects.
Advances in the understanding of myocarditis.
TLDR
The objective of this article is to better define myocarditis for both clinicians and clinical scientists by setting it in the framework of 3 phases of disease, in which the viral stage is reviewed, the autoimmune phase is examined and the remodeling processes are considered.
...
...