Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment.

@article{Macdonald2004EffectsOS,
  title={Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment.},
  author={John E Macdonald and Nola Kennedy and Allan D. Struthers},
  journal={Heart},
  year={2004},
  volume={90 7},
  pages={765-70}
}
OBJECTIVES To examine whether the favourable effects on endothelial function, vascular angiotensin converting enzyme (ACE) activity, cardiac remodelling, autonomic function, and QT intervals of spironolactone in combination with ACE inhibitor also occur in patients with New York Heart Association class I-II congestive heart failure (CHF) taking optimal treatment (including beta blockers). METHODS Double blind, crossover study comparing 12.5-50 mg/24 hours spironolactone (three months) with… CONTINUE READING

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Endothelial function : a barometer of cardiovascular risk

  • E Harada, M Yoshimura, H Yasue
  • Circulation
  • 2002

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