Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro.


The effects of eight components from six commonly consumed spices on P-glycoprotein (P-gp) transport and CYP3A4 metabolism were evaluated in vitro. P-gp-mediated [(3)H]digoxin fluxes across the L-MDR1 (LLC-PK1 cells transfected with human MDR1 gene) and Caco-2 (human colon carcinoma) cell monolayers showed a marked asymmetry compared with that in the LLC… (More)
DOI: 10.1124/dmd.107.019737

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