Effects of specific antibody Fab fragments on desipramine pharmacokinetics in the rat in vivo and in the isolated, perfused liver.

@article{Keyler1995EffectsOS,
  title={Effects of specific antibody Fab fragments on desipramine pharmacokinetics in the rat in vivo and in the isolated, perfused liver.},
  author={Daniel E. Keyler and David G. Le Couteur and Susan M. Pond and John V. St. Peter and Paul R. Pentel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 3},
  pages={1117-23}
}
Drug-specific antibody fragments, which can reverse tricyclic antidepressant toxicity in rats, represent a potential clinical treatment for tricyclic antidepressant overdose in humans. To delineate the pharmacokinetic mechanisms, we studied the effects of a high-affinity, drug-specific Fab fragment on desipramine (DMI) disposition in rats and on DMI kinetics in the isolated, perfused rat liver. These studies were performed at high DMI and Fab doses, with Fab administered at the time of peak DMI… CONTINUE READING