Effects of species-dependent differences in action potential shape in setting β-adrenergic-stimulation induced current


In canine (D) and human, but not guinea pig (GP), ventricular myocytes, a spike-and-dome profile (SaD), supported by Ito, characterizes ventricular repolarization. β-adrenergic stimulation (by isoprenaline, ISO) shortens action potential (AP) duration (APD) in D (and human) myocytes, but prolongs it in GP ones. Aim: The aim of this work is to clarify… (More)


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