Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice.

@article{Bharal2006EffectsOS,
  title={Effects of sparfloxacin on CNS functions and urinary hydroxyproline in mice.},
  author={Nidhi Bharal and Krishna Kolappa Pillai and Divya Vohora},
  journal={Pharmacological research},
  year={2006},
  volume={54 2},
  pages={
          111-7
        }
}
Sparfloxacin is a widely prescribed drug for various infections. In the present study, sparfloxacin, at two doses, 25 and 50 mg kg(-1) was screened on seven neurological and neurobehavioural parameters in mice. In addition, a chronic study was performed to measure the grip strength of the animal to simulate tendon damage and corresponding hydroxyproline levels were determined in mice urine. Increasing current electroshock test (ICES), pentylenetetrazole (PTZ)-induced seizures, forced swim test… 
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