Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice.

@article{Luijten2004EffectsOS,
  title={Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice.},
  author={Mirjam Luijten and Anni R\onfeldt Thomsen and Jolanda A H van den Berg and Piet W. Wester and Aart Verhoef and Nico J. D. Nagelkerke and Herman C T Adlercreutz and Henk J van Kranen and Aldert H. Piersma and Ilona Kryspin S\orensen and G. Naga Malleshwara Rao and Coen F van Kreijl},
  journal={Nutrition and cancer},
  year={2004},
  volume={50 1},
  pages={46-54}
}
Phytoestrogens such as isoflavonoids and lignans have been postulated as breast cancer protective constituents in soy and whole-grain cereals. We investigated the ability of isoflavones (IFs) and flaxseed to modulate spontaneous mammary tumor development in female heterozygous Tg.NK (MMTV/c-neu) mice. Two different exposure protocols were applied, either from 4 wk of age onward (postweaning) or during gestation and lactation (perinatal). In the postweaning exposure study, mice were fed IFs or… CONTINUE READING