Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.

@article{Ng1998EffectsOS,
  title={Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.},
  author={T F Ng and Francesca K M Lee and Zhigang Song and Nigel A. Calcutt and Alice S Y Lee and Stephen S M Chung and Sookja Kim Chung},
  journal={Diabetes},
  year={1998},
  volume={47 6},
  pages={961-6}
}
In this report, we made use of sorbitol dehydrogenase (SDH)-deficient mutant mice (C57BL/LiA) to test whether there is a close correlation between the level of polyol accumulation and the degree of reduction in motor nerve conduction velocity (MNCV) associated with diabetes. The C57BL/LiA mouse has SDH deficiency due to a G-to-A mutation at the +1 position of intron 8, thus producing only aberrant SDH transcripts. These C57BL/LiA mice should have higher levels of polyol accumulation in the… CONTINUE READING