Effects of some xenobiotics on ascorbic acid metabolism in rats.

@article{Horio1982EffectsOS,
  title={Effects of some xenobiotics on ascorbic acid metabolism in rats.},
  author={Fumihiko Horio and Akira Yoshida},
  journal={The Journal of nutrition},
  year={1982},
  volume={112 3},
  pages={
          416-25
        }
}
The administration of xenobiotics, PCB, DDT, or aminopyrine to rats causes a marked increase in urinary excretion of ascorbic acid and in various tissue levels of ascorbic acid. When rats were fed diet containing 200 ppm PCB or 500 ppm DDT (14 days), the incorporations from D-(U-14C) glucose into ascorbic acid in liver were significantly increased. The dietary addition of 200 ppm PCB, 500 ppm DDT, 2,000 ppm pentobarbital or 3,000 ppm chloretone caused a significant increase in the activity of… CONTINUE READING

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