Effects of some tricyclic psychopharmacons and structurally related compounds on motility ofProteus vulgaris

  title={Effects of some tricyclic psychopharmacons and structurally related compounds on motility ofProteus vulgaris},
  author={J{\'a}nos Moln{\'a}r and Jie Ren and Jette Elisabeth Kristiansen and Masahiro Nakamura},
  journal={Antonie van Leeuwenhoek},
A simple test for the evaluation of drugs interfering with bacterial motility was established withProteus vulgaris. With this model, promethazine, 7-hydroxy-chlorpromazine, imipramine, 7,8-dioxochlorpromazine and acridine orange were shown to exert significant motility and swarming inhibitory action onProteus vulgaris strains at subinhibitory concentrations. Quinidine enhanced the antimotility effect of promethazine. The antimotility effect of promethazine was synergized by proton pump… 

Psychotropic drugs inhibit swarming in Proteus spp. and related genera

Some psychotropic drugs, and mainly some selective serotonin re-uptake inhibitors, such as sertraline, are able to inhibit swarming in Proteus and related species.

The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria.

It is suppose that the inhibiton of bacterial motility is related to the virulence of bacteria: consequently the pathogenicity can be reduced in the presence of TF18.

Effect of some psychotropic drugs and a barbiturate on mycoplasmas.


In vivo studies with this component showed that it could offer statistically significant protection to Swiss Albino mice challenged with 50X Minimum Lethal Dose (MLD) of a virulent bacterium, Salmonella enterica serovar Typhimurium NCTC 74.

Do phenothiazines possess antimicrobial and efflux inhibitory properties?

It is discussed how the use of antibiotic adjuvants can minimise the appearance and impact of resistance, and the evidence to suggest that phenothiazines possess inherent antibacterial and efflux inhibitory properties enabling them to potentially combat drug resistance.

Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB.

The information collated suggests that this phenothiazine has the potential to cure XDR and MDR tuberculosis infections, a potential that has been recently demonstrated by its ability to cure 10 patients who presented with XDR TB infections.

Study of Metformin Effect on Antimicrobial Property

The present study showed that effectiveness of metformin drug on microbes showed a pronounced inhibitory action against Pseudomonas aeruginosa, an organism which is known to be multidrug resistant.

Modulation of Antibiotic Efficacy against Klebsiella pneumoniae byAntihistaminic Drugs

The data obtained showed that, among the tested drugs promethazine and cyproheptadine exerted high antibacterial activity against MDR K. pneumoniae isolates, and it is possible to take the advantages of the obtained findings to introduce new ways to overcome different infectious diseases.

Biological Evaluation of Products Formed from the Irradiation of Chlorpromazine with a 266 nm Laser Beam

The products of prolonged irradiation of CPZ produced increasingly significant concentration dependent inhibition of efflux by the Salmonella strains.



Antiplasmid activity of tricyclic compounds.

  • J. Molnár
  • Biology
    Methods and findings in experimental and clinical pharmacology
  • 1988
This approach utilizes the beneficial side-effect of the plasmid curing ability of these psychopharmacons, and may serve as a guideline for drug design in the future, to develop related substances which are potent in eliminating the drug resistance-carrying plasmids of bacteria, but which have no other pharmacological effects.

The antibacterial action and R-factor-inhibiting activity by chlorpromazine

Die grampositiven Bakterienstämme waren empfindlicher gegen Chlorpromazin als die gramnegativen, während Chlor Promazin keinerlei Wirkung auf die Vermehrung vonPseudomonas aeruginosa hatte.

Drug interaction of promethazine & other non-conventional antimicrobial chemotherapeutic agents.

The antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive

Tricyclic drugs reduce proton motive force in Leishmania donovani promastigotes.

Experiments to Illustrate The Effect Of Chlorpromazine On The Permeability Of The Bacterial Cell Wall

  • J. Kristiansen
  • Biology
    Acta pathologica et microbiologica Scandinavica. Section B, Microbiology
  • 1979
It has been shown that concentrations of CPZ near the bacteriostatic value, in combination with bacterial haemolysins, alters erythrocyte membranes (horse and rabbit) in such a way that they become resistant to haemophilia and changes the transport of potassium through the bacterial membrane in the same manner as described for mammalian muscle tissue.

The antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues.

It is demonstrated that psychotherapeutic drugs have an antimicrobial effect and the need for a general theory of the interplay between host organism, microorganisms and drugs is argued.

The influence of charge transfer complex formation on the antibacterial activity of some tricyclic drugs.

As a consequence of competitive inhibition between bacterial binding sites and xanthine dyes, the binding energy of drugs in the plasmid replication system could be determined in the presence of dyes and the anti-plasmid action of the phenothiazines was decreased.

Calcium and calmodulin antagonists inhibit human malaria parasites (Plasmodium falciparum): implications for drug design.

It is found by radioimmunoassay that free parasites contain CaM, and the in vitro growth of Plasmodium falciparum was sensitive to CaM antagonists, and inhibition of the parasite was proportional to known anti-CaM potency.

l-Serine Deaminase of Escherichia coli

The native l-serine deaminase of Escherichia coli K-12, which seems to be a very labile protein, is rather stable in concentrated solution, whereas the enzyme liberated from the bacteria in the presence of l-Serine exhibits normal Michaelis-Menten kinetics.