Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin

  title={Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin},
  author={Seiji Kuzuna and Shigeru Morimoto and Kiyohisa Kawai},
  journal={Agents and Actions},
Gerber has shown that specific anti-rheumatics,d-penicillamine and aurothiomalate, inhibit coppert(II)-catalyzed thermal aggregation of human gamma globulin. Various anti-rheumatics were tested for the activity. Steroidal and non-steroidal anti-inflammatory agents were almost ineffective, while a new non-steroidal anti-inflammatory agent, TAI-284 (6-chloro-5-cyclohexyl-1-indancarboxylic acid), was found to be one half as active as aurothiomalate. The structure-activity relationship of TAI-284… 

Anti-Inflammatory Effects of The Chloroform Extract of Annona muricata Leaves on Phospholipase A2 and Prostaglandin Synthase Activities

The triggering of inflammation leads to the release of inflammatory mediators which can either be cell-derived or plasma-derived, which include vasoactive amines, cytokines, nitric oxide, prostaglandins, thromboxane A2 (TXA2), prostacyclin, leukotrienes and plateletactivating factor.

Anti-inflammatory activities of crude ethanol extract of Combretum zenkeri Engl. & Diels leaves

This study shows that EECZ possess anti-inflammatory activities that could be through the inhibition of PLA2 activity and platelet aggregation, and membrane stabilization.

Evaluation of the anti-inflammatory and analgesic activities of Vitex doniana leaves

The anti-inflammatory and analgesic activities of extract of leaves of Vitex donianaSweet (Verbenaceae) were investigated as well as the mechanisms of action, suggesting that the leaves possess anti- inflammation and analgesics activities mediated through sequential inhibition of the enzymes responsible for prostaglandin synthesis from arachidonic acid.



Copper-catalyzed thermal aggregation of human gamma-globulin. Inhibition by histidine, gold thiomalate, and penicillamine.

  • D. Gerber
  • Medicine, Biology
    Arthritis and rheumatism
  • 1974
Gold thiomalate, penicillamine, and histidine inhibit the copper-catalyzed thermal aggregation of human gamma globulin and adds support to the hypothesis that the hypohistidinemia of rheumatoid arthritis participates in the pathogenesis of the disease.

Anti-inflammatory, analgesic and antipyretic activities of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284).

Presentation of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284), which has strong antiinflammatory, analgesic, and antipyretic activities, which is revived with successful introduction of some agents on the market.

Copper complexes - a unique class of anti-arthritic drugs.

Biologic activity of aggregated gamma-globulin. II. A study of various methods for aggregation and species differences.

The mechanism for the induction of the biologic activities by the formation of aggregated γ-globulin and of antigen-antibody complexes was discussed.

Biological activities of metabolites of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).

The pharmacological activities of five metabolites of an anti-inflammatory compound, 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284) were investigated and compared with TAI-284 and phenylbutazone to study the distribution pattern and affinity of the metabolites for receptors.

Response to autologous immunoglobulin G in patients with rheumatoid arthritis.

It has been suggested that the chronic inflammation characteristic of rheumatoid arthritis (RA) repre-sents an immunopathological response to an exo- genous or endogenous constituent present in the

Enhancement of human lymphocyte transformation by aggregated human gamma globulin.

  • T. Kinsella
  • Medicine, Biology
    The Journal of clinical investigation
  • 1974
It is suggested that aggFII may enhance intra-articular lymphocyte transformation in subjects with RA because substrates similar to those employed in these studies are present in vivo in the rheumatoid joint.

Biological activities of optical isomers of 6-chloro-5-cyclohexylindan-1-carboxylic acid (TAI-284: anti-inflammatory agent).

-A potent anti-inflammatory compound, TAI-284, and its optical isomers were subjected to the pharmacological, toxicological and metabolic studies in rats, mice and guinea-pigs. In anti-inflammatory,

Trace metal composition of synovial fluid from patients with rheumatoid arthritis.

Synovial fluid and blood serum from patients with rheumatoid arthritis and from subjects free of symptoms of connective tissue disease were analyzed by emission spectrography. Synovial fluid of

Chronic synovitis in rheumatoid arthritis.