Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin

@article{Kuzuna2005EffectsOS,
  title={Effects of some anti-rheumatic agents on copper-catalyzed thermal aggregation of gamma globulin},
  author={Seiji Kuzuna and Shigeru Morimoto and Kiyohisa Kawai},
  journal={Agents and Actions},
  year={2005},
  volume={9},
  pages={375-380}
}
Gerber has shown that specific anti-rheumatics,d-penicillamine and aurothiomalate, inhibit coppert(II)-catalyzed thermal aggregation of human gamma globulin. Various anti-rheumatics were tested for the activity. Steroidal and non-steroidal anti-inflammatory agents were almost ineffective, while a new non-steroidal anti-inflammatory agent, TAI-284 (6-chloro-5-cyclohexyl-1-indancarboxylic acid), was found to be one half as active as aurothiomalate. The structure-activity relationship of TAI-284… 

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