Effects of some adrenergic and cholinergic drugs on isolated spleen strips from the cod, Gadus morhua.

@article{Holmgren1975EffectsOS,
  title={Effects of some adrenergic and cholinergic drugs on isolated spleen strips from the cod, Gadus morhua.},
  author={Susanne Holmgren and Stefan U Nilsson},
  journal={European journal of pharmacology},
  year={1975},
  volume={32 02},
  pages={163-9}
}
The effects of drugs on isolated spleen strips from the cod, Gadus morhua, have been investigated. Affinities and intrinsic activities for various agonists were determined from cumulative dose-response curves. Contractions were produced by acetylcholine, methacholine or carbachol. The response to acetylcholine was considerably potentiated by the acetylcholinesterase inhibitor BW 284 C51. Methacholine-induced responses were competitively blocked by atropine (pA2 = 8.2), indicating the presence… CONTINUE READING
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